Back to Search
Start Over
Novel therapies and preventative strategies for primary and recurrent Clostridium difficile infections.
- Source :
-
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2019 Jan; Vol. 1435 (1), pp. 110-138. Date of Electronic Publication: 2018 Sep 21. - Publication Year :
- 2019
-
Abstract
- Clostridium difficile is the leading infectious cause of antibiotic-associated diarrhea and colitis. C. difficile infection (CDI) places a heavy burden on the healthcare system, with nearly half a million infections yearly and an approximate 20% recurrence risk after successful initial therapy. The high incidence has driven new research on improved prevention such as the emerging use of probiotics, intestinal microbiome manipulation during antibiotic therapies, vaccinations, and newer antibiotics that reduce the disruption of the intestinal microbiome. While the treatment of acute C. difficile is effective in most patients, it can be further optimized by adjuvant therapies that improve the initial treatment success and decrease the risk of subsequent recurrence. Finally, the high risk of recurrence has led to multiple emerging therapies that target toxin activity, recovery of the intestinal microbial community, and elimination of latent C. difficile in the intestine. In summary, CDIs illustrate the complex interaction among host physiology, microbial community, and pathogen that requires specific therapies to address each of the factors leading to primary infection and recurrence.<br /> (© 2018 New York Academy of Sciences.)
- Subjects :
- Drug Resistance, Bacterial drug effects
Drug Resistance, Bacterial genetics
Humans
Anti-Bacterial Agents therapeutic use
Clostridioides difficile genetics
Clostridioides difficile pathogenicity
Clostridium Infections drug therapy
Clostridium Infections genetics
Clostridium Infections pathology
Colitis drug therapy
Colitis genetics
Colitis microbiology
Diarrhea drug therapy
Diarrhea genetics
Diarrhea microbiology
Gastrointestinal Microbiome genetics
Microbiota genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1749-6632
- Volume :
- 1435
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 30238983
- Full Text :
- https://doi.org/10.1111/nyas.13958