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Pregnancy managed by unfractionated heparin after mechanical aortic valve replacement.
- Source :
-
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2020 Mar; Vol. 33 (6), pp. 1030-1032. Date of Electronic Publication: 2018 Sep 19. - Publication Year :
- 2020
-
Abstract
- Pregnancy after mechanical valve replacement involves high risk. Maternal valve thrombosis and hemorrhagic complications are associated with lethal outcomes; therefore, strict anticoagulant therapy is needed. Our patient was 26-year-old primiparous woman. She had undergone aortic valve replacement with a mechanical valve at 4 years of age and had used warfarin 3 mg per day since then. Because of her desire for a baby, she stopped warfarin and conceived spontaneously. She was referred to our hospital. After being informed of her choices, unfractionated heparin (UFH) administration was started. She experienced mild heart failure with sacroiliitis, bacteremia, and hematuria during pregnancy. She delivered her newborn at 37 weeks. Blood loss at delivery was 220 g. Administration of UFH was restarted 4 h after delivery and 3 mg of warfarin was administered from postpartum day (PPD) 6. Hemostatic suturing was required for vaginal bleeding on PPD7. A therapeutic dose of warfarin was achieved on PPD9. Although warfarin use is recommended as anticoagulant therapy for pregnant woman with mechanical valves, the safety and efficacy of UFH have not yet been clarified because of its limited use. More cases are needed to clarify this.
- Subjects :
- Adult
Anticoagulants therapeutic use
Aortic Valve surgery
Drug Administration Schedule
Female
Heparin therapeutic use
Humans
Pregnancy
Anticoagulants administration & dosage
Heart Valve Prosthesis Implantation
Heparin administration & dosage
Postnatal Care methods
Postoperative Complications drug therapy
Pregnancy Complications, Cardiovascular drug therapy
Prenatal Care methods
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4954
- Volume :
- 33
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
- Publication Type :
- Academic Journal
- Accession number :
- 30231658
- Full Text :
- https://doi.org/10.1080/14767058.2018.1512573