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Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities.
- Source :
-
Free radical biology & medicine [Free Radic Biol Med] 2018 Dec; Vol. 129, pp. 155-168. Date of Electronic Publication: 2018 Sep 15. - Publication Year :
- 2018
-
Abstract
- Mitochondrial dysfunction characterized by impaired bioenergetics, oxidative stress and aldehydic load is a hallmark of heart failure. Recently, different research groups have provided evidence that selective activation of mitochondrial detoxifying systems that counteract excessive accumulation of ROS, RNS and reactive aldehydes is sufficient to stop cardiac degeneration upon chronic stress, such as heart failure. Therefore, pharmacological and non-pharmacological approaches targeting mitochondria detoxification may play a critical role in the prevention or treatment of heart failure. In this review we discuss the most recent findings on the central role of mitochondrial dysfunction, oxidative stress and aldehydic load in heart failure, highlighting the most recent preclinical and clinical studies using mitochondria-targeted molecules and exercise training as effective tools against heart failure.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Aldehydes antagonists & inhibitors
Aldehydes metabolism
Animals
Clinical Trials as Topic
Disease Models, Animal
Drug Evaluation, Preclinical
Energy Metabolism drug effects
Exercise
Heart Failure metabolism
Heart Failure pathology
Humans
Malondialdehyde antagonists & inhibitors
Malondialdehyde metabolism
Mitochondria, Heart metabolism
Mitochondria, Heart pathology
Oxidative Stress drug effects
Reactive Nitrogen Species antagonists & inhibitors
Reactive Nitrogen Species metabolism
Reactive Oxygen Species antagonists & inhibitors
Reactive Oxygen Species metabolism
Superoxide Dismutase chemistry
Ubiquinone therapeutic use
Antioxidants therapeutic use
Biomimetic Materials therapeutic use
Cardiotonic Agents therapeutic use
Heart Failure therapy
Mitochondria, Heart drug effects
Ubiquinone analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4596
- Volume :
- 129
- Database :
- MEDLINE
- Journal :
- Free radical biology & medicine
- Publication Type :
- Academic Journal
- Accession number :
- 30227272
- Full Text :
- https://doi.org/10.1016/j.freeradbiomed.2018.09.019