Regulation of sex hormone receptors in sexual dimorphism of human cancers.

Authors :: Zheng D
Williams C
Vold JA
Nguyen JH
Harnois DM
Bagaria SP
McLaughlin SA
Li Z
Source :: Cancer letters [Cancer Lett] 2018 Dec 01; Vol. 438, pp. 24-31. Date of Electronic Publication: 2018 Sep 14.
Publication Year :: 2018
Abstract: Gender differences in the incidences of cancers have been found in almost all human cancers. However, the mechanisms that underlie gender disparities in most human cancer types have been under-investigated. Here, we provide a comprehensive overview of potential mechanisms underlying sexual dimorphism of each cancer regarding sex hormone signaling. Fully addressing the mechanisms of sexual dimorphism in human cancers will greatly benefit current development of precision medicine. Our discussions of potential mechanisms underlying sexual dimorphism in each cancer will be instructive for future cancer research on gender disparities.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)