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Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility.
- Source :
-
Fish & shellfish immunology [Fish Shellfish Immunol] 2018 Dec; Vol. 83, pp. 238-242. Date of Electronic Publication: 2018 Sep 13. - Publication Year :
- 2018
-
Abstract
- Changes to lipid metabolism are well-characterised consequences of human tuberculosis infection but their functional relevance are not clearly elucidated in these or other host-mycobacterial systems. The zebrafish-Mycobacterium marinum infection model is used extensively to model many aspects of human-M. tuberculosis pathogenesis but has not been widely used to study the role of infection-induced lipid metabolism. We find mammalian mycobacterial infection-induced alterations in host Low Density Lipoprotein metabolism are conserved in the zebrafish model of mycobacterial pathogenesis. Depletion of LDLR, a key lipid metabolism node, decreased M. marinum burden, and corrected infection-induced altered lipid metabolism resulting in decreased LDL and reduced the rate of macrophage transformation into foam cells. Our results demonstrate a conserved role for infection-induced alterations to host lipid metabolism, and specifically the LDL-LDLR axis, across host-mycobacterial species pairings.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Cholesterol, LDL metabolism
Disease Models, Animal
Embryo, Nonmammalian
Lipid Metabolism
Mycobacterium Infections, Nontuberculous veterinary
Receptors, LDL genetics
Zebrafish
Zebrafish Proteins genetics
Fish Diseases metabolism
Mycobacterium Infections, Nontuberculous metabolism
Receptors, LDL metabolism
Zebrafish Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9947
- Volume :
- 83
- Database :
- MEDLINE
- Journal :
- Fish & shellfish immunology
- Publication Type :
- Academic Journal
- Accession number :
- 30219383
- Full Text :
- https://doi.org/10.1016/j.fsi.2018.09.037