FGF23 beyond Phosphotropic Hormone.

Authors :: Takashi Y
Fukumoto S
Source :: Trends in endocrinology and metabolism: TEM [Trends Endocrinol Metab] 2018 Nov; Vol. 29 (11), pp. 755-767. Date of Electronic Publication: 2018 Sep 11.
Publication Year :: 2018
Abstract: Fibroblast growth factor (FGF) 23 is a bone-derived phosphotropic hormone that regulates phosphate and vitamin D metabolism. FGF23 mainly affects kidney function via the FGF receptor (FGFR)/α-Klotho complex. The physiological roles of FGF23 and α-Klotho in the regulation of mineral homeostasis have been well established. In addition, recent studies have reported that FGF23 has various effects on many other tissues, sometimes in an α-Klotho-independent manner, especially under pathological conditions. However, how FGF23 works in these tissues without α-Klotho is not entirely clear. Here we review the recent reports concerning the actions of FGF23 on various tissues and discuss the remaining questions about FGF23.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)