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Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2018 Sep 12; Vol. 23 (9). Date of Electronic Publication: 2018 Sep 12. - Publication Year :
- 2018
-
Abstract
- A series of novel spirooxindole- O -naphthoquinone-tetrazolo[1,5- a ]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents. These hybrids exhibited relatively high cytotoxic activity against cancer cell line HepG2 (IC <subscript>50</subscript> = 2.86⁻36.34 μM), while normal cell line LO2 was less sensitive to these hybrids (IC <subscript>50</subscript> = 36.37⁻248.39 μM). On the whole, among all the compounds tested, compound 4e , with a mean IC <subscript>50</subscript> value of 2.86 μM, was the most active. The novel hybrids may find their pharmaceutical applications after further investigations.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Cell Line
Cell Survival drug effects
Drug Design
Drug Screening Assays, Antitumor
Hep G2 Cells
Humans
Molecular Structure
Naphthoquinones chemistry
Naphthoquinones pharmacology
Pyrimidines chemistry
Pyrimidines pharmacology
Spiro Compounds chemistry
Spiro Compounds pharmacology
Antineoplastic Agents chemical synthesis
Naphthoquinones chemical synthesis
Pyrimidines chemical synthesis
Spiro Compounds chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 23
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 30213123
- Full Text :
- https://doi.org/10.3390/molecules23092330