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Heat Shock Proteins in Alzheimer's Disease: Role and Targeting.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2018 Sep 01; Vol. 19 (9). Date of Electronic Publication: 2018 Sep 01. - Publication Year :
- 2018
-
Abstract
- Among diseases whose cure is still far from being discovered, Alzheimer's disease (AD) has been recognized as a crucial medical and social problem. A major issue in AD research is represented by the complexity of involved biochemical pathways, including the nature of protein misfolding, which results in the production of toxic species. Considering the involvement of (mis)folding processes in AD aetiology, targeting molecular chaperones represents a promising therapeutic perspective. This review analyses the connection between AD and molecular chaperones, with particular attention toward the most important heat shock proteins (HSPs) as representative components of the human chaperome: Hsp60, Hsp70 and Hsp90. The role of these proteins in AD is highlighted from a biological point of view. Pharmacological targeting of such HSPs with inhibitors or regulators is also discussed.
- Subjects :
- Amyloid beta-Peptides
Animals
Enzyme Inhibitors chemistry
Enzyme Inhibitors therapeutic use
Humans
Models, Animal
tau Proteins metabolism
Alzheimer Disease drug therapy
Alzheimer Disease metabolism
Chaperonin 60 metabolism
HSP70 Heat-Shock Proteins metabolism
HSP90 Heat-Shock Proteins metabolism
Mitochondrial Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 19
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 30200516
- Full Text :
- https://doi.org/10.3390/ijms19092603