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The changing landscape of naloxone availability in the United States, 2011 - 2017.
- Source :
-
Drug and alcohol dependence [Drug Alcohol Depend] 2018 Oct 01; Vol. 191, pp. 361-364. Date of Electronic Publication: 2018 Aug 30. - Publication Year :
- 2018
-
Abstract
- Opioid overdose deaths have been on the rise in the United States since 1999. Naloxone is a competitive opioid antagonist that rapidly reverses opioid overdose. The implementation of naloxone access laws and development of naloxone formulations that can be administered by laypersons have coincided with changes in the landscape of naloxone availability in the United States. Using data from IQVIA's National Prescription Audit <superscript>®</superscript> we present the number of naloxone prescriptions dispensed quarterly from 2011 through the second quarter of 2017. The data demonstrate that nationwide naloxone dispensing increased nearly eight-fold from the fourth quarter of 2015 to the second quarter of 2017. Narcan <superscript>®</superscript> was the most commonly prescribed naloxone formulation as of the second quarter of 2017, accounting for 68% of prescriptions during that quarter followed by Evzio <superscript>®</superscript> (20%). There was considerable variability in the extent to which states experienced increases in naloxone dispensing, which may represent a general state-specific response to the opioid crisis, rather than direct association with opioid overdose death rates in a particular state. Although naloxone access laws continue to increase the amount of naloxone dispensed, cost remains a concern in terms of wide distribution of the life-saving medication.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Analgesics, Opioid adverse effects
Analgesics, Opioid therapeutic use
Drug Prescriptions
Humans
United States epidemiology
Drug Overdose drug therapy
Drug Overdose epidemiology
Naloxone therapeutic use
Narcotic Antagonists therapeutic use
Opioid-Related Disorders drug therapy
Opioid-Related Disorders epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0046
- Volume :
- 191
- Database :
- MEDLINE
- Journal :
- Drug and alcohol dependence
- Publication Type :
- Academic Journal
- Accession number :
- 30195192
- Full Text :
- https://doi.org/10.1016/j.drugalcdep.2018.07.017