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Baicalin exerts neuroprotective effects via inhibiting activation of GSK3β/NF-κB/NLRP3 signal pathway in a rat model of depression.
- Source :
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International immunopharmacology [Int Immunopharmacol] 2018 Nov; Vol. 64, pp. 175-182. Date of Electronic Publication: 2018 Sep 06. - Publication Year :
- 2018
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Abstract
- Chronic stress can provoke depressive-like behaviors through activation of inflammation and apoptosis, leading to a reduction of neurons. Antidepressant therapy may contribute to inhibiting inflammation responses and have neuroprotective effects. Baicalin (BA) has an antidepressant effect in the chronic unpredictable mild stress (CUMS) animal model and exerts anti-inflammation, anti-apoptosis, as well as neuroprotective effects in many central nervous system (CNS)-related diseases. But the effects of BA on neuroprotection, apoptosis, and neuroinflammation and the potential mechanisms in depression are unclear. Here, we focused on examining the therapeutic effects of BA in CUMS-induced depression rats and investigating the molecular mechanisms. Results showed that administration of BA improved depressive-like behaviors and significantly increased the levels of doublecortin (DCX), Neuron-specific enolase (NSE), and Brain-derived neurotrophic factor (BDNF) in hippocampus. Furthermore, administration of BA increased the cell survival by reducing the level of malondialdehyde (MDA) and increasing the level of superoxide dismutase (SOD). Finally, administration of BA significantly decreased CUMS-induced apoptosis and inflammatory cytokines (caspase-1 and IL-1β) in hippocampus. These responses were mediated by Glycogen synthase kinase-3 (GSK3) β/Nuclear factor-κB (NF-κB)/Nucleotide-binding domain, leucine-rich repeat, pyrin domain containing protein 3 (NLRP3) signal pathway. Taken together, these results indicate that BA could promote neuronal maturation and rescue neurons from apoptosis via inhibiting activation of GSK3β/NF-κB/NLRP3 signal pathway that is known to be associated with inflammation, thus exerting neuroprotective effects and preventing CUMS-induced depressive-like behaviors.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Apoptosis drug effects
Depression etiology
Doublecortin Protein
Flavonoids therapeutic use
Glycogen Synthase Kinase 3 beta physiology
Hippocampus drug effects
Hippocampus physiology
Male
Motor Activity drug effects
NF-kappa B physiology
NLR Family, Pyrin Domain-Containing 3 Protein physiology
Rats
Rats, Sprague-Dawley
Depression drug therapy
Flavonoids pharmacology
Glycogen Synthase Kinase 3 beta antagonists & inhibitors
NF-kappa B antagonists & inhibitors
NLR Family, Pyrin Domain-Containing 3 Protein antagonists & inhibitors
Neuroprotective Agents pharmacology
Signal Transduction drug effects
Stress, Psychological complications
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1705
- Volume :
- 64
- Database :
- MEDLINE
- Journal :
- International immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 30195108
- Full Text :
- https://doi.org/10.1016/j.intimp.2018.09.001