Synergistic inhibition of human T-cell lymphotropic virus type III replication in vitro by phosphonoformate and recombinant alpha-A interferon.

Authors :: Hartshorn KL
Sandstrom EG
Neumeyer D
Paradis TJ
Chou TC
Schooley RT
Hirsch MS
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1986 Jul; Vol. 30 (1), pp. 189-91.
Publication Year :: 1986
Abstract: Phosphonoformate and recombinant alpha-A interferon synergistically inhibited the replication of human T-cell lymphotropic virus type III in cultured peripheral blood lymphocytes. T-cell proliferative capability was maintained by this combination, and toxicity was minimal.

Subjects :: Cells, Cultured
Drug Synergism
Foscarnet
Humans
Lymphocytes microbiology
Phosphonoacetic Acid analogs & derivatives
Recombinant Proteins pharmacology
Deltaretrovirus drug effects
Interferon Type I pharmacology
Organophosphorus Compounds pharmacology
Phosphonoacetic Acid pharmacology
Virus Replication drug effects

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