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Circulating microRNAs expression profile in newly diagnosed and imatinib treated chronic phase - chronic myeloid leukemia.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2019 Mar; Vol. 60 (3), pp. 805-811. Date of Electronic Publication: 2018 Sep 06. - Publication Year :
- 2019
-
Abstract
- Chronic myeloid leukemia (CML) is a stem cell derived malignant disorder result of translocation t(9;22)(q34;q11) called Philadelphia chromosome (Ph <superscript>+</superscript> ). microRNAS (miRNAs) are involved in several biological processes, altering the progression of various pathologies, including CML. This study evaluated whether circulating miRNAs display differential expression profiles in peripheral blood of CML-Chronic Phase (CML-CP) patients newly diagnosed in comparison with CML-CP treated with imatinib. We obtained peripheral blood samples from CML-CP Ph <superscript>+</superscript> patients divided among group 1 (untreated newly diagnosed) and group 2 (treated with imatinib). A pool of total leukocytes from healthy donors was considered as control group. Expression analyses were performed for 768 miRNAs by RT-qPCR array. Bioinformatic tools were used to identify significant pathways and interaction networks. We found 80 deregulated miRNAs between the groups and, according to bioinformatic analysis, they are involved in different pathways, including molecular mechanisms of cancer. The study allows better understanding of disease molecular behavior, and it is useful for possible monitoring CML treatment and prognostic biomarkers identification.
- Subjects :
- Computational Biology methods
Gene Expression Profiling
Gene Expression Regulation, Leukemic
Humans
Imatinib Mesylate administration & dosage
Imatinib Mesylate adverse effects
Leukemia, Myeloid, Chronic-Phase blood
Leukemia, Myeloid, Chronic-Phase diagnosis
Protein Kinase Inhibitors administration & dosage
Protein Kinase Inhibitors adverse effects
Biomarkers, Tumor
Circulating MicroRNA
Imatinib Mesylate therapeutic use
Leukemia, Myeloid, Chronic-Phase drug therapy
Leukemia, Myeloid, Chronic-Phase genetics
Protein Kinase Inhibitors therapeutic use
Transcriptome
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 60
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 30188232
- Full Text :
- https://doi.org/10.1080/10428194.2018.1499905