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Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration.
- Source :
-
Cell reports [Cell Rep] 2018 Sep 04; Vol. 24 (10), pp. 2540-2552.e6. - Publication Year :
- 2018
-
Abstract
- RNA-binding proteins Lin28a/b regulate cellular growth and tissue regeneration. Here, we investigated the role of Lin28 in the control of axon regeneration in postmitotic neurons. We find that Lin28a/b are both necessary and sufficient for supporting axon regeneration in mature sensory neurons through their regulatory partners, let-7 microRNAs (miRNAs). More importantly, overexpression of Lin28a in mature retinal ganglion cells (RGCs) produces robust and sustained optic nerve regeneration. Additionally, combined overexpression of Lin28a and downregulation of Pten in RGCs act additively to promote optic nerve regeneration, potentially by reducing the backward turning of regenerating RGC axons. Our findings not only reveal a vital role of Lin28 signaling in regulating mammalian axon regeneration but also identify a signaling pathway that can promote axon regeneration in the central nervous system (CNS).<br /> (Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Axons metabolism
Cells, Cultured
Electroporation
Female
Male
Mice
Nerve Regeneration genetics
Nerve Regeneration physiology
Optic Nerve metabolism
Optic Nerve physiology
Optic Nerve Injuries metabolism
PTEN Phosphohydrolase genetics
PTEN Phosphohydrolase metabolism
RNA-Binding Proteins genetics
Retinal Ganglion Cells cytology
Retinal Ganglion Cells metabolism
Signal Transduction genetics
Signal Transduction physiology
Axons physiology
Central Nervous System cytology
Central Nervous System metabolism
Peripheral Nervous System cytology
Peripheral Nervous System metabolism
RNA-Binding Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2211-1247
- Volume :
- 24
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Cell reports
- Publication Type :
- Academic Journal
- Accession number :
- 30184489
- Full Text :
- https://doi.org/10.1016/j.celrep.2018.07.105