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Crystalline Sponge Method Enabled the Investigation of a Prenyltransferase-terpene Synthase Chimeric Enzyme, Whose Product Exhibits Broadened NMR Signals.
- Source :
-
Organic letters [Org Lett] 2018 Sep 21; Vol. 20 (18), pp. 5606-5609. Date of Electronic Publication: 2018 Sep 04. - Publication Year :
- 2018
-
Abstract
- By the genome-mining approach, a chimeric enzyme of prenyltransferase-diterpene synthase was discovered from Penicillium chrysogenum MT-12. Since its product exhibited broadened NMR signals, the structural determination by only the NMR analysis was difficult, but the crystalline sponge method successfully revealed the structure with a 6-5-5-5 fused ring system. This demonstrated that the collaboration between the genome-mining and crystalline sponge method has the potential to facilitate rapid inquiries into the unexplored chemical space of small molecules.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 20
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 30179018
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b02284