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So similar and so different: Circulating androgens and androgen origin in bulimic women.
- Source :
-
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2019 Jan; Vol. 185, pp. 184-188. Date of Electronic Publication: 2018 Aug 30. - Publication Year :
- 2019
-
Abstract
- Hyper androgen state frequently can be diagnosed in bulimic women. Eating disorder not otherwise specified (EDNOS) recognized as a less severe form of bulimia nervosa (BN). The objective of the study was to determine whether androgen levels and androgen origin differs in bulimic women compared to control subjects. Forty-six women with bulimia nervosa (BN), 31 with eating disorder not otherwise specified, purging type (EDNOS P) and 56 matched healthy controls were studied with respect to serum testosterone (T), 5alpha-dihydrotestosterone (DHT), sex hormone-binding globulin (SHBG), deyhydroepiahndrosterone sulfate (DHEAS) and luteinizing hormone (LH) and to ovarian morphology. Despite all groups had almost identical androgen and SHBG levels; there were differences in the origin of circulating T and DHT. Correlation analysis suggest major differences in the formation of circulating testosterone (T) and 5α-dihydrotestosterone (DHT) with BN being more like the control subjects with peripheral formation from 4-androsterne-3,17-dione (A-4), dehydroepiandrosterone sulfate (DHEAS) and also from T. While in EDNOS group a possible direct ovarian T secretion and a DHEAS modulating action of androgens on pituitary gonadotropin secretion is present. The origin of circulating T and DHT differs between bulimics. Our findings do probably not reflect direct actions of circulating DHT on pituitary LH secretion in the women with EDNOS, but rather the effect of A-4, T via conversion to DHT in the central nervous system, indicating psych/endocrine differences between the two groups of bulimic women.<br /> (Copyright © 2018. Published by Elsevier Ltd.)
- Subjects :
- Adult
Female
Gonadotropins, Pituitary metabolism
Humans
Menstruation Disturbances complications
Ovarian Follicle physiology
Androgens blood
Bulimia Nervosa blood
Dehydroepiandrosterone Sulfate blood
Dihydrotestosterone blood
Luteinizing Hormone blood
Sex Hormone-Binding Globulin analysis
Testosterone blood
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1220
- Volume :
- 185
- Database :
- MEDLINE
- Journal :
- The Journal of steroid biochemistry and molecular biology
- Publication Type :
- Academic Journal
- Accession number :
- 30172682
- Full Text :
- https://doi.org/10.1016/j.jsbmb.2018.08.013