Enantioselective Intramolecular Copper-Catalyzed Borylacylation.

Authors :: Whyte A
Burton KI
Zhang J
Lautens M
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2018 Oct 15; Vol. 57 (42), pp. 13927-13930. Date of Electronic Publication: 2018 Sep 21.
Publication Year :: 2018
Abstract: An enantioselective copper-catalyzed intramolecular borylacylation is reported. The reaction proceeds through an initial enantioselective borylcupration of the styrene, followed by a nucleophilic attack on the tethered carbamoyl chloride. The products, chiral borylated 3,3-disubstituted oxindoles, were generated in excellent yields and enantioselectivities. The versatile carbon-boron bond provides a platform for a wide array of diversification.<br /> (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)