Back to Search
Start Over
Evaluation of pancreatic exocrine functions in rheumatoid arthritis.
- Source :
-
Bratislavske lekarske listy [Bratisl Lek Listy] 2018; Vol. 119 (8), pp. 494-497. - Publication Year :
- 2018
-
Abstract
- Background: Rheumatoid arthritis (RA) is one of the most common chronic inflammatory diseases. It mainly involves the joints and also affects directly or indirectly nearly all organ systems. The question whether RA causes exocrine pancreatic disfunction remains unclear. The purpose of this study is to evaluate whether or not RA contributes to pancreatic exocrine insufficiency. This was done by ruling out seconder Sjögren's syndrome (SjS) by using Schirmer's test.<br />Methods: A total of 60 patients (20 RA, 20 RA + SjS and 20 SjS) and 20 healthy volunteers were included in the study. Patients with RA who had not undergonethe Schirmer's test in the last 6 months and all healthy volunteers included in the study underwent the Schirmer's test at an outpatient clinic. Random fecal samples were taken from all participants and fecal pancreatic elastase was measured to evaluate pancreatic exocrine functions.<br />Results: In the study, a statistically significant difference was found between the control group,SjS and RA+SjS groups. But there was no significant difference between the control group and RA group. In RA group, fecal elastase levels were statistically significantly higher compared to the SjS group. But there was no significant difference between RA+SjS and SjS groups.<br />Conclusion: Fecal elastase significantly decreased in SjS compared to the normal population while pancreatic exocrine functions are considered to be impaired in SjS. There are also impaired pancreatic exocrine functions in the secondary SjS associated with RA. Consequently, pancreatic exocrine dysfunction, which can be seen in patients with RA, may be thought to be caused by secondary SjS associated with RA (Tab. 6, Fig. 1, Ref. 19).
- Subjects :
- Adult
Aged
Case-Control Studies
Feces enzymology
Female
Humans
Male
Middle Aged
Pancreatic Function Tests methods
Arthritis, Rheumatoid physiopathology
Exocrine Pancreatic Insufficiency physiopathology
Pancreas physiopathology
Pancreas, Exocrine physiopathology
Pancreatic Elastase metabolism
Sjogren's Syndrome physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-9248
- Volume :
- 119
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Bratislavske lekarske listy
- Publication Type :
- Academic Journal
- Accession number :
- 30160157
- Full Text :
- https://doi.org/10.4149/BLL_2018_090