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Association of T-helper cell cytokine level with age in patients with biliary atresia: a preliminary study.

Authors :
Li FB
Shu XL
Gu WZ
Zhao XX
Huang SJ
Zhao H
Peng KR
Tou JF
Source :
World journal of pediatrics : WJP [World J Pediatr] 2018 Aug; Vol. 14 (4), pp. 404-409. Date of Electronic Publication: 2018 Aug 29.
Publication Year :
2018

Abstract

Background: The pathogenesis of biliary atresia (BA) is associated with an inflammatory process involving the biliary tree. This study aimed to investigate the association of T-helper cell cytokine levels with age in patients with BA.<br />Methods: Twenty-eight patients with BA were divided into three groups according to their age (< 2 months, 2-3 months, and ≥ 3 months). All the patients underwent Kasai portoenterostomy. Blood samples were collected from the patients preoperatively, and the liver tissue specimens were obtained during surgery. We detected serum levels of interleukin (IL)-1β, IL-12p70, interferon (IFN)-γ, IL-6, IL-10, and transforming growth factor (TGF)-β1 and liver expression of IL-1β, IL-6, and TGF-β1.<br />Results: The serum levels of IL-1β, IL-12p70, IL-6, and IL-10 in patients aged ≥ 3 months were significantly higher than those in patients aged < 2 months. There were no significant age-related differences in the IL-1β, IL-6 and TGF-β1 expression levels in the liver tissue of patients with BA.<br />Conclusions: The serum levels of IL-1β, IL-6, IL-10 and IL-12p70 showed significant age-related differences in patients with BA. Interpretation of the role of cytokines in BA needs to take patient's age into consideration.

Details

Language :
English
ISSN :
1867-0687
Volume :
14
Issue :
4
Database :
MEDLINE
Journal :
World journal of pediatrics : WJP
Publication Type :
Academic Journal
Accession number :
30159734
Full Text :
https://doi.org/10.1007/s12519-018-0183-1