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Fibroblast growth factor 21 inhibits atherosclerosis in apoE-/- mice by ameliorating Fas-mediated apoptosis.
- Source :
-
Lipids in health and disease [Lipids Health Dis] 2018 Aug 29; Vol. 17 (1), pp. 203. Date of Electronic Publication: 2018 Aug 29. - Publication Year :
- 2018
-
Abstract
- Background: FGF21 is a critical endogenous regulator in energy homeostasis and systemic glucose and lipid metabolism. Despite intensive study of the metabolic functions of FGF21, its important role in heart disease needs further exploration. Apoptosis induced by ox-LDL in vascular endothelial cells is an important step in the progress of atherosclerosis.<br />Methods: The effects of FGF21 treatment on apoptosis induced by ox-LDL were tested in HUVECs. The role of FGF21 in atherosclerosis was studied by evaluating its function in apolipoprotein E double knockout (apoE-/-) mice.<br />Results: We found that apoptosis in HUVECs was alleviated by FGF21 treatment. The effects of FGF21 were independent of the ERK1/2 pathway and were mediated through inhibition of the Fas signaling pathway. FGF21 suppressed the development of atherosclerosis, and the administration of FGF21 ameliorated Fas-mediated apoptosis in apoE-/- mice.<br />Conclusion: FGF21 protects against apoptosis in HUVECs by suppressing the expression of Fas; furthermore, FGF21 alleviated atherosclerosis by ameliorating Fas-mediated apoptosis in apoE-/- mice.
- Subjects :
- Animals
Apolipoproteins E metabolism
Cytoprotection drug effects
Fibroblast Growth Factors pharmacology
Human Umbilical Vein Endothelial Cells drug effects
Human Umbilical Vein Endothelial Cells metabolism
Humans
Lipoproteins, LDL pharmacology
MAP Kinase Signaling System drug effects
Mice, Inbred C57BL
Mice, Knockout
Apolipoproteins E deficiency
Apoptosis drug effects
Atherosclerosis drug therapy
Atherosclerosis pathology
Fibroblast Growth Factors therapeutic use
fas Receptor metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1476-511X
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Lipids in health and disease
- Publication Type :
- Academic Journal
- Accession number :
- 30157856
- Full Text :
- https://doi.org/10.1186/s12944-018-0846-x