Back to Search
Start Over
Influence of hemodynamics on enlarged perivascular spaces in atherosclerotic large vessel disease.
- Source :
-
Neurological research [Neurol Res] 2018 Dec; Vol. 40 (12), pp. 1021-1027. Date of Electronic Publication: 2018 Aug 29. - Publication Year :
- 2018
-
Abstract
- Objectives: Enlarged perivascular spaces (EPVS) are often observed in small vessel disease on T2-weighted images. However, their role in ischemic conditions caused by cerebral large vessel disease remains unclear. We evaluated EPVS in patients with hemodynamic compromise associated with atherosclerotic large vessel disease and aimed to identify the pathophysiology of EPVS.<br />Methods: We examined 28 adults with atherosclerotic large vessel disease. EPVS numbers in the basal ganglia and the centrum semiovale were assessed. For each affected hemisphere, the total numbers of EPVS were compared with those on the unaffected side. EPVS in the impaired hemodynamics group were compared with those in the unimpaired hemodynamics group. Moreover, EPVS were compared in the presence/absence of large stroke.<br />Results: The number of EPVS was significantly increased on the affected side in the centrum semiovale (p = 0.023), particularly in the impaired hemodynamics group (p = 0.006). Moreover, in the small stroke subgroup of the impaired hemodynamics group, the number of EPVS was significantly increased on the affected side (p = 0.002), although this number was insignificant in the large ischemic stroke subgroup.<br />Conclusions: The number of EPVS was increased in patients with atherosclerotic large vessel disease with hemodynamic compromise and decreased in the presence of a large stroke. EPVS might act as fluid absorbers in a hemodynamically compromised state until the occurrence of an ischemic stroke.
- Subjects :
- Aged
Atherosclerosis diagnostic imaging
Basal Ganglia diagnostic imaging
Brain Edema diagnostic imaging
Cerebral Small Vessel Diseases diagnostic imaging
Female
Humans
Iofetamine pharmacokinetics
Lateral Ventricles diagnostic imaging
Magnetic Resonance Imaging
Male
Middle Aged
Statistics, Nonparametric
Tomography, Emission-Computed, Single-Photon
Atherosclerosis complications
Basal Ganglia pathology
Brain Edema etiology
Cerebral Small Vessel Diseases complications
Hemodynamics physiology
Lateral Ventricles pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1743-1328
- Volume :
- 40
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Neurological research
- Publication Type :
- Academic Journal
- Accession number :
- 30156508
- Full Text :
- https://doi.org/10.1080/01616412.2018.1509827