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Non-Directed Cross-Dehydrogenative (Hetero)arylation of Allylic C(sp 3 )-H bonds enabled by C-H Activation.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2018 Nov 12; Vol. 57 (46), pp. 15248-15252. Date of Electronic Publication: 2018 Oct 12. - Publication Year :
- 2018
-
Abstract
- Herein, we report the selective, non-directed and cross-dehydrogenative coupling of allylic C(sp <superscript>3</superscript> )-H bonds with C(sp <superscript>2</superscript> )-H bonds of (hetero)arenes. The methodology employs olefins and (hetero)arenes which are abundantly available chemical feedstocks, and could be applied in late-stage functionalization reactions of pharmaceuticals. Furthermore, the system exclusively delivers the allylic C-C coupling products highlighting the preservation of the olefin substitution pattern for further derivatization.<br /> (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 57
- Issue :
- 46
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 30152920
- Full Text :
- https://doi.org/10.1002/anie.201807047