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Coordination Modulation Method To Prepare New Metal-Organic Framework-Based CO-Releasing Materials.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2018 Sep 19; Vol. 10 (37), pp. 31158-31167. Date of Electronic Publication: 2018 Sep 07. - Publication Year :
- 2018
-
Abstract
- Aluminum-based metal-organic frameworks (MOFs), [Al(OH)(SDC)] <subscript>n</subscript> , (H <subscript>2</subscript> SDC: 4,4'-stilbenedicarboxylic acid), also known as CYCU-3, were prepared by means of the coordination modulation method to produce materials with different crystal size and morphology. In particular, we screened several reagent concentrations (20-60 mM) and modulator/ligand ratios (0-50), leading to 20 CYCU x&#95; y materials ( x: reagent concentration, y = modulator/ligand ratio) with different particle size and morphology. Noteworthy, the use of high modulator/ligand ratio gives rise to a new phase of CYCU-3 (CYCU-3' x&#95;50 series), which was structurally analyzed. Afterward, to test the potential of these materials as CO-prodrug carriers, we selected three of them to adsorb the photo- and bioactive CO-releasing molecule (CORM) ALF794 [Mo(CNCMe <subscript>2</subscript> CO <subscript>2</subscript> H) <subscript>3</subscript> (CO) <subscript>3</subscript> ] (CNCMe <subscript>2</subscript> CO <subscript>2</subscript> H = 2-isocyano-2-methyl propionic acid): (i) CYCU-3 20&#95;0, particles in the nanometric range; (ii) CYCU-3 50&#95;5, bar-type particles with heterogeneous size, and (iii) CYCU-3' 50&#95;50, a new phase analogous to pristine CYCU-3. The corresponding hybrid materials were fully characterized, revealing that CYCU-3 20&#95;0 with the smallest particle size was not stable under the drug loading conditions. Regarding the other two materials, similar ALF794 loadings were found (0.20 and 0.19 CORM/MOF molar ratios for ALF794@CYCU-3 50&#95;5 and ALF794@CYCU-3' 50&#95;50, respectively). In addition, these hybrid systems behave as CO-releasing materials (CORMAs), retaining the photoactive properties of the pristine CORM in both phosphate saline solution and solid state. Finally, the metal leaching studies in solution confirmed that ALF794@CYCU-3' 50&#95;50 shows a good retention capacity toward the potentially toxic molybdenum fragments (75% of retention after 72 h), which is the lowest value reported for a MOF-based CORMA to date.
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 10
- Issue :
- 37
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 30152684
- Full Text :
- https://doi.org/10.1021/acsami.8b11758