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Calibration of the 7th British Working Standard for factors II, IX and X, concentrate.
- Source :
-
Biologicals : journal of the International Association of Biological Standardization [Biologicals] 2018 Nov; Vol. 56, pp. 63-66. Date of Electronic Publication: 2018 Aug 24. - Publication Year :
- 2018
-
Abstract
- Seven laboratories from 5 different countries participated in the calibration of the 7th British Working Standard (BWS) for blood coagulation factors II, IX and X. The candidate, 15/182, was assayed for Factors II and X potencies against the 4th International Standard (IS) for Factors II and X, Concentrate (11/126) and for Factor IX potency against the 5th IS for Factor IX, Concentrate (14/148). Intra-laboratory GCVs for all 3 factors were less than 10%, with the majority less than 5%. Inter-laboratory GCVs were 3.4%, 3.2% and 2.3% for FII, IX and X respectively. All participants agreed with the value assigned and preparation 15/182 was established by NIBSC in October 2017 as the 7th BWS for FII, IX, X Concentrate with potencies of 6.0 IU/ampoule, 6.7 IU/ampoule and 4.9 IU/ampoule for FII, IX and X respectively.<br /> (Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1095-8320
- Volume :
- 56
- Database :
- MEDLINE
- Journal :
- Biologicals : journal of the International Association of Biological Standardization
- Publication Type :
- Academic Journal
- Accession number :
- 30146418
- Full Text :
- https://doi.org/10.1016/j.biologicals.2018.08.007