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Bioactive food and exercise in chronic kidney disease: Targeting the mitochondria.

Authors :
Mafra D
Gidlund EK
Borges NA
Magliano DC
Lindholm B
Stenvinkel P
von Walden F
Source :
European journal of clinical investigation [Eur J Clin Invest] 2018 Nov; Vol. 48 (11), pp. e13020. Date of Electronic Publication: 2018 Sep 16.
Publication Year :
2018

Abstract

Chronic kidney disease (CKD), which affects 10%-15% of the population, associates with a range of complications-such as cardiovascular disease, frailty, infections, muscle and bone disorders and premature ageing-that could be related to alterations of mitochondrial number, distribution, structure and function. As mitochondrial biogenesis, bioenergetics and the dynamic mitochondrial networks directly or indirectly regulate numerous intra- and extracellular functions, the mitochondria have emerged as an important target for interventions aiming at preventing or improving the treatment of complications in CKD. In this review, we discuss the possible role of bioactive food compounds and exercise in the modulation of the disturbed mitochondrial function in a uraemic milieu.<br /> (© 2018 Stichting European Society for Clinical Investigation Journal Foundation.)

Details

Language :
English
ISSN :
1365-2362
Volume :
48
Issue :
11
Database :
MEDLINE
Journal :
European journal of clinical investigation
Publication Type :
Academic Journal
Accession number :
30144313
Full Text :
https://doi.org/10.1111/eci.13020