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Paricalcitol supplementation during the first year after kidney transplantation does not affect calcification propensity score.
- Source :
-
BMC nephrology [BMC Nephrol] 2018 Aug 22; Vol. 19 (1), pp. 212. Date of Electronic Publication: 2018 Aug 22. - Publication Year :
- 2018
-
Abstract
- Background: Cardiovascular complications are common in kidney transplant patients and calcification propensity of blood, measured as T <subscript>50</subscript> , is associated with cardiovascular outcomes. Paricalcitol supplementation affects calcium/phosphate homeostasis and may affect calcification propensity. To assess this hypothesis we measured T <subscript>50</subscript> in kidney transplant recipients participating in a randomized study comparing paricalcitol versus no treatment during the first year after kidney transplantation.<br />Methods: Stored serum samples from 76 kidney transplant recipients (paricalcitol n = 37, no treatment n = 39) were analyzed. Analyses were performed at inclusion (8 weeks after transplantation) and repeated one year after transplantation.<br />Results: There were no statistically significant differences in T <subscript>50</subscript> between the paricalcitol and placebo groups, neither at baseline (p = 0.56) nor at 1 year (p = 0.61). Also, there were no significant changes in T <subscript>50</subscript> over time in either group or when pooling all data (p <  0.20). In multivariate regression analysis, out of 16 potentially relevant covariates, comprising clinical and biochemical parameters, only plasma PTH and T <subscript>50</subscript> at baseline were significantly correlated to T <subscript>50</subscript> after one year. (p <  0.03 and p < 0.01, respectively).<br />Conclusions: Calcium propensity measured as T <subscript>50</subscript> score remained unchanged with paricalcitol treatment in kidney transplant recipients, and was not changed over time during the study period of one year.<br />Trial Registration: ClinicalTrials.gov, NCT01694160 , registered 23 September 2012.
- Subjects :
- Adult
Aged
Bone Density Conservation Agents adverse effects
Calcinosis chemically induced
Calcinosis epidemiology
Ergocalciferols adverse effects
Female
Humans
Kidney Transplantation adverse effects
Male
Middle Aged
Norway epidemiology
Renal Insufficiency, Chronic blood
Renal Insufficiency, Chronic epidemiology
Renal Insufficiency, Chronic therapy
Bone Density Conservation Agents administration & dosage
Calcinosis blood
Calcium blood
Ergocalciferols administration & dosage
Kidney Transplantation trends
Propensity Score
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2369
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 30134956
- Full Text :
- https://doi.org/10.1186/s12882-018-1000-8