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Paths to expansion: Differential requirements of IRF4 in CD8 + T-cell expansion driven by antigen and homeostatic cytokines.
- Source :
-
European journal of immunology [Eur J Immunol] 2018 Aug; Vol. 48 (8), pp. 1281-1284. - Publication Year :
- 2018
-
Abstract
- Interferon regulatory factor 4 (IRF4) regulates the clonal expansion and metabolic activity of activated T cells, but the precise context and mechanisms of its function in these processes are unclear. In this issue of the European Journal of Immunology, Miyakoda et al. [Eur. J. Immunol. 2018. 48: 1319-1328] show that IRF4 is required for activation and expansion of naïve and memory CD8 <superscript>+</superscript> T cells driven by T-cell receptor (TCR) signaling, but dispensable for memory CD8 <superscript>+</superscript> T-cell maintenance and homeostatic proliferation driven by homeostatic cytokines. The authors show that the function of IRF4 in CD8 <superscript>+</superscript> T-cell expansion is partially dependent upon activation of the PI3K/AKT pathway through direct or indirect attenuation of PTEN expression. These data shed light upon the differential intracellular pathways required for naïve and memory T cells to respond to self-antigens and/or homeostatic cytokines, and highlight the potential translational relevance of these findings in the context of immune reconstitution such as following allogeneic stem cell transplantation.<br /> (© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Animals
Cell Differentiation immunology
Cell Proliferation
Immunologic Memory immunology
Lymphocyte Activation immunology
Mice
PTEN Phosphohydrolase metabolism
Phosphatidylinositol 3-Kinases metabolism
Proto-Oncogene Proteins c-akt metabolism
Signal Transduction immunology
CD8-Positive T-Lymphocytes immunology
Interferon Regulatory Factors immunology
Receptors, Antigen, T-Cell immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4141
- Volume :
- 48
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 30133745
- Full Text :
- https://doi.org/10.1002/eji.201847727