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HTLV-III antibody and T-cell subset ratios in haemophiliacs and their spouses.
- Source :
-
British journal of haematology [Br J Haematol] 1986 Jun; Vol. 63 (2), pp. 347-52. - Publication Year :
- 1986
-
Abstract
- 44% of 63 British patients with either haemophilia A or B were HTLV-III antibody positive (HTLV-VIII+). HTLV-III+ was more frequent in high factor VIII concentrate users and 75% of severely affected haemophilia A patients were HTLV-III+. All eight patients who were exposed to factor IX concentrate were HTLV-III-. 17 haemophilia A patients who received only British made factor VIII concentrate (average 12,000 units/year) were HTLV-III-. Two of 63 patients had evidence of a pre-AIDS type symptom complex and both were HTLV-III+. Information from a cohort of 21 Liverpool haemophiliacs suggests that HTLV-III was first introduced into this country in 1981. OKT4/T8 ratios were abnormal in 52% of 21 patients studied but this finding was not confined to either HTLV-III+ or HTLV-III- individuals. The spouses of 14 HTLV-III+ haemophiliacs were all HTLV-III-.
- Subjects :
- Adolescent
Adult
Aged
Child
Factor VIII therapeutic use
Family
Female
Hemophilia A drug therapy
Hemophilia A genetics
Hemophilia B drug therapy
Humans
Male
Middle Aged
Antibodies, Viral analysis
Deltaretrovirus immunology
Hemophilia A immunology
Hemophilia B immunology
T-Lymphocytes classification
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1048
- Volume :
- 63
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 3013274
- Full Text :
- https://doi.org/10.1111/j.1365-2141.1986.tb05558.x