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The association between risk of limb fracture and type 2 diabetes mellitus.

Authors :: Liu J
Cao L
Qian YW
Chen ZX
Guo SF
Sun WQ
He ZR
Source :: Oncotarget [Oncotarget] 2018 Jan 05; Vol. 9 (58), pp. 31302-31310. Date of Electronic Publication: 2018 Jan 05 (Print Publication: 2018).
Publication Year :: 2018
Abstract: Background: Recently, increasing reports showed that the risk of fracture may be correlated with type 2 diabetes mellitus (T2DM). However, their results still remained controversial. Thus we performed a meta-analysis including 11 studies to estimate the risk factor of limb fracture in type 2 diabetes mellitus.<br />Materials and Methods: Databases including PubMed, Embase, Cochrane Library and Web of Science were searched to September, 2017. Risk Ratio (RR) with its 95% confidence intervals (CI) was used to evaluate the association between risk of limb fracture and type 2 diabetes mellitus. Two reviewers assessed the quality of all the included studies and extracted data for analysis independently.<br />Results: A total of 11 studies including 663,923 participants were included in this meta-analysis. Our analysis results showed that patients with type 2 diabetes mellitus had a significant association with risk of limb fracture (RR 1.18; 95% CI 1.02-1.35), including leg or ankle fracture (RR 1.80; 95% CI 1.13-2.87). Subgroup analysis showed individuals with type 2 diabetes had almost two-fold excessive risk of leg/ankle fracture in women and the pooled RR of leg/ankle fracture was 2.03 (95% CI 1.36-3.05; P = 0.0006).<br />Conclusions: The results of the present meta-analysis showed that individuals with type 2 diabetes mellitus had higher risk of limb fractures, and this relationship is more pronounced in leg or ankle fracture.<br />Competing Interests: CONFLICTS OF INTEREST The author declared no conflicts of interests.