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Development and evaluation of a CEACAM6-targeting theranostic nanomedicine for photoacoustic-based diagnosis and chemotherapy of metastatic cancer.
- Source :
-
Theranostics [Theranostics] 2018 Jul 30; Vol. 8 (15), pp. 4247-4261. Date of Electronic Publication: 2018 Jul 30 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Metastasis is the leading cause of cancer-related deaths. A number of chemotherapeutic and early diagnosis strategies, including nanomedicine, have been developed to target metastatic tumor cells. However, simultaneous inhibition and imaging of metastasis is yet to be fully achieved. Methods: To overcome this limitation, we have developed human serum albumin-based nanoparticles (tHSA-NPs) with photoacoustic imaging capability, which target carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6). CEACAM6 is highly expressed in metastatic anoikis-resistant tumor cells. Results: In vitro , the CEACAM6-targeting tHSA-NPs efficiently targeted CEACAM6-overexpressing metastatic anoikis-resistant tumor cells. In vivo , CEACAM6-targeting tHSA-NPs administered intravenously to BALB/c nude mice efficiently inhibited lung metastasis in circulating anoikis-resistant tumor cells compared to the controls. In addition, anoikis-resistant tumor cells can be successfully detected by photoacoustic imaging, both in vitro and in vivo, using the intrinsic indocyanine green-binding affinity of albumin. Conclusion: In summary, the CEACAM6-targeting albumin-based nanoparticles allowed the delivery of drugs and photoacoustic imaging to metastatic anoikis-resistant tumor cells in vitro and in vivo . Based on the expression of CEACAM6 in a variety of tumors, CEACAM6-targeting nanomedicine might be used to target various types of metastatic tumor cells.<br />Competing Interests: Competing Interests: The authors have declared that no competing interest exists.
- Subjects :
- A549 Cells
Adenocarcinoma therapy
Animals
Antineoplastic Agents administration & dosage
Disease Models, Animal
Doxorubicin administration & dosage
GPI-Linked Proteins analysis
Humans
Mice, Inbred BALB C
Mice, Nude
Molecular Targeted Therapy methods
Serum Albumin administration & dosage
Adenocarcinoma diagnostic imaging
Antigens, CD analysis
Cell Adhesion Molecules analysis
Drug Therapy methods
Lung Neoplasms secondary
Nanoparticles administration & dosage
Photoacoustic Techniques methods
Theranostic Nanomedicine methods
Subjects
Details
- Language :
- English
- ISSN :
- 1838-7640
- Volume :
- 8
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Theranostics
- Publication Type :
- Academic Journal
- Accession number :
- 30128051
- Full Text :
- https://doi.org/10.7150/thno.25131