Back to Search
Start Over
Functional interplay between c-Myc and Max in B lymphocyte differentiation.
- Source :
-
EMBO reports [EMBO Rep] 2018 Oct; Vol. 19 (10). Date of Electronic Publication: 2018 Aug 20. - Publication Year :
- 2018
-
Abstract
- The Myc family of oncogenic transcription factors regulates myriad cellular functions. Myc proteins contain a basic region/helix-loop-helix/leucine zipper domain that mediates DNA binding and heterodimerization with its partner Max. Among the Myc proteins, c-Myc is the most widely expressed and relevant in primary B lymphocytes. There is evidence suggesting that c-Myc can perform some of its functions in the absence of Max in different cellular contexts. However, the functional in vivo interplay between c-Myc and Max during B lymphocyte differentiation is not well understood. Using in vivo and ex vivo models, we show that while c-Myc requires Max in primary B lymphocytes, several key biological processes, such as cell differentiation and DNA replication, can initially progress without the formation of c-Myc/Max heterodimers. We also describe that B lymphocytes lacking Myc, Max, or both show upregulation of signaling pathways associated with the B-cell receptor. These data suggest that c-Myc/Max heterodimers are not essential for the initiation of a subset of important biological processes in B lymphocytes, but are required for fine-tuning the initial response after activation.<br /> (© 2018 The Authors.)
- Subjects :
- Amino Acid Sequence genetics
Animals
B-Lymphocytes metabolism
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors chemistry
DNA Replication genetics
DNA-Binding Proteins chemistry
DNA-Binding Proteins genetics
Dimerization
Helix-Loop-Helix Motifs genetics
Humans
Leucine Zippers genetics
Mice
Protein Binding genetics
Proto-Oncogene Proteins c-myc chemistry
Transcriptional Activation genetics
B-Lymphocytes chemistry
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors genetics
Cell Differentiation genetics
Proto-Oncogene Proteins c-myc genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1469-3178
- Volume :
- 19
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- EMBO reports
- Publication Type :
- Academic Journal
- Accession number :
- 30126925
- Full Text :
- https://doi.org/10.15252/embr.201845770