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Complete sequence of the ANKK1 gene in Mexican-Mestizo individuals with obesity, with or without binge eating disorder.
- Source :
-
European psychiatry : the journal of the Association of European Psychiatrists [Eur Psychiatry] 2018 Oct; Vol. 54, pp. 59-64. Date of Electronic Publication: 2018 Aug 16. - Publication Year :
- 2018
-
Abstract
- Background: The aim of this study was to investigate if Mexican-Mestizo individuals with obesity, with or without binge eating disorder (BED), exhibited mutations or other type of genetic variants in the sequence of ANKK1.<br />Subjects and Methods: Fifty unrelated individuals (21-53 years of age) with obesity, of Mexican-Mestizo ethnic origin were included; 25 of them had BED and 25 presented obesity without BED. The diagnosis of BED was based on criteria proposed in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Besides, we also analyzed 100 individuals with normal body mass index. DNA from blood leukocytes was amplified by the polymerase chain reaction and all exons of ANKK1 were sequenced.<br />Results: After ANKK1 sequencing we did not find any mutations; however, we observed various polymorphisms. One polymorphism, rs4938013 in exon 2 showed an association with obesity, whilst rs1800497 (also known as Taq1A) in exon 8, showed an association with BED (P = 0.020). Remarkable, for this study, the number of individuals for both polymorphisms for and additive model was sufficient to derive strong statistical power (80%, with a P < 0.05).<br />Conclusions: To our knowledge, this constitutes the first report where the complete sequences of ANKK1 has been analyzed in individuals with obesity, with or without BED. No mutations were found; however, one polymorphism was associated with obesity, with or without BED, and another one was associated with BED.<br /> (Copyright © 2018 Elsevier Masson SAS. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1778-3585
- Volume :
- 54
- Database :
- MEDLINE
- Journal :
- European psychiatry : the journal of the Association of European Psychiatrists
- Publication Type :
- Academic Journal
- Accession number :
- 30121507
- Full Text :
- https://doi.org/10.1016/j.eurpsy.2018.07.010