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Effect of Artemisia herba-alba consumption during pregnancy on fertility, morphological and behaviors of mice offspring.
- Source :
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Journal of ethnopharmacology [J Ethnopharmacol] 2018 Nov 15; Vol. 226, pp. 105-110. Date of Electronic Publication: 2018 Aug 16. - Publication Year :
- 2018
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Abstract
- Ethnopharmacological Relevance: Pregnant women prefer herbal medicines more than pharmaceutical drugs due to the cultural belief that herbs are more suffer during pregnancy for an accurate foetus development. Artemisia herba-alba (Asteraceae) is one of the most used plants in the Mediterranean region to treat various diseases including diabetes, hypertension, spasmodic dysphonia and some bacterial infection.<br />Aim of the Study: The present study aimed to investigate the effect of Artemisia herba-alba consumption during pregnancy on fertility, physical and behavior developments of mice offspring from birth-to-weaning days.<br />Materials and Methods: Female pregnant mice were divided into three groups and orally administrated with 80 and 150 mg/kg/day of the methanol extract of Artemisia h.a respectively, during the entire period of gestation. At birth, total fertility rate was counted. Body development; neuromotor reflex and behavior were also examined in mice offspring RESULTS: Artemisia h.a (Aha) exposure significantly decreased the fertility ratio in both Aha-treated groups and increased the weight and length of mice offspring in 80 mg/kg/day Aha-exposed group. Moreover, Aha administration prolonged the time of completing the reflex response of surface righting, negative geotaxis, cliff avoidance and jumping test of mice offspring in Aha-exposed groups.<br />Conclusion: The present study provides strong evidence that discourage the use of Artemisia h.a during gestation period.<br /> (Copyright © 2018. Published by Elsevier B.V.)
Details
- Language :
- English
- ISSN :
- 1872-7573
- Volume :
- 226
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 30118834
- Full Text :
- https://doi.org/10.1016/j.jep.2018.08.017