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Quantitative analysis of the dose-response of white spot syndrome virus in shrimp.
- Source :
-
Journal of fish diseases [J Fish Dis] 2018 Nov; Vol. 41 (11), pp. 1733-1744. Date of Electronic Publication: 2018 Aug 17. - Publication Year :
- 2018
-
Abstract
- White spot syndrome virus (WSSV) is an important cause of mortality and economic losses in shrimp farming. Although WSSV-induced mortality is virus dose dependent and WSSV infection does not necessarily lead to mortality, the relationships between virus-particle dose, infection and mortality have not been analysed quantitatively. Here, we explored WSSV dose-response by a combination of experiments, modelling and meta-analysis. We performed dose-response experiments in Penaeus vannamei postlarvae, recorded host mortality and detected WSSV infection. When we fitted infection models to these data, two models-differing in whether they incorporated heterogeneous host susceptibility to the virus or not-were supported for two independent experiments. To determine the generality of these results, we reanalysed published data sets and then performed a meta-analysis. We found that WSSV dose-response kinetics is indeed variable over experiments. We could not clearly identify which specific infection model has the most support by meta-analysis, but we argue that these results also are most concordant with a model incorporating varying levels of heterogeneous host susceptibility to WSSV. We have identified suitable models for analysing WSSV dose-response, which can elucidate the most basic virus-host interactions and help to avoid underestimating WSSV infection at low virus doses.<br /> (© 2018 The Authors. Journal of Fish Diseases Published by John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1365-2761
- Volume :
- 41
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of fish diseases
- Publication Type :
- Academic Journal
- Accession number :
- 30117593
- Full Text :
- https://doi.org/10.1111/jfd.12877