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The Efficacy of Buprenorphine in Major Depression, Treatment-Resistant Depression and Suicidal Behavior: A Systematic Review.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2018 Aug 15; Vol. 19 (8). Date of Electronic Publication: 2018 Aug 15. - Publication Year :
- 2018
-
Abstract
- Although several pharmacological options to treat depression are currently available, approximately one third of patients who receive antidepressant medications do not respond adequately or achieve a complete remission. Thus, novel strategies are needed to successfully address those who did not respond, or partially respond, to available antidepressant pharmacotherapy. Research findings revealed that the opioid system is significantly involved in the regulation of mood and incentives salience and may be an appropriate target for novel therapeutic agents. The present study aimed to systematically review the current literature about the use of buprenorphine (BUP) for major depression, treatment-resistant depression (TRD), non-suicidal self-injury (NSSI) behavior, and suicidal behavior. We investigated Pubmed and Scopus databases using the following keywords: "buprenorphine AND depression", "buprenorphine AND treatment resistant depression", "buprenorphine AND suicid*", "buprenorphine AND refractory depression". Several evidence demonstrate that, at low doses, BUP is an efficacious, well-tolerated, and safe option in reducing depressive symptoms, serious suicidal ideation, and NSSI, even in patients with TRD. However, more studies are needed to evaluate the long-term effects, and relative efficacy of specific combinations (e.g., BUP + samidorphan (BUP/SAM), BUP + naloxone (BUP/NAL), BUP + naltrexone) over BUP monotherapy or adjunctive BUP treatment with standard antidepressants, as well as to obtain more uniform guidance about the optimal BUP dosing interval.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Analgesics, Opioid administration & dosage
Analgesics, Opioid adverse effects
Buprenorphine administration & dosage
Buprenorphine adverse effects
Depressive Disorder, Treatment-Resistant drug therapy
Humans
Suicidal Ideation
Analgesics, Opioid therapeutic use
Buprenorphine therapeutic use
Depressive Disorder, Major drug therapy
Suicide Prevention
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 19
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 30111745
- Full Text :
- https://doi.org/10.3390/ijms19082410