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MiRNAs and their interplay with PI3K/AKT/mTOR pathway in ovarian cancer cells: a potential role in platinum resistance.
- Source :
-
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2018 Dec; Vol. 144 (12), pp. 2313-2318. Date of Electronic Publication: 2018 Aug 14. - Publication Year :
- 2018
-
Abstract
- Ovarian cancer is a leading cause of death among gynecologic malignancies. This disappointing prognosis is closely related to intrinsic or acquired resistance to conventional platinum-based chemotherapy, which can affect a third of patients. As such, investigating relevant molecular targets is crucial in the fight against this disease. So far, many mutations involved in ovarian cancer pathogenesis have been identified. Among them, a few pathways were implicated. One such pathway is the P13K/AKT/mTOR with abnormalities found in many cases. This pathway is considered to have an instrumental role in proliferation, migration, invasion and, more recently, in chemotherapy resistance. Many miRNAs have been found to influence P13K/AKT/mTOR pathway with different potential role in tumor genesis and ovarian cancer behaviour. In particular, their biological function was recently investigated as regards chemoresistance, therefore, leading to the identification of potential specific indirect biomarker of platinum sensitivity in ovarian cancer.
- Subjects :
- Drug Resistance, Neoplasm genetics
Epigenesis, Genetic
Female
Humans
Ovarian Neoplasms drug therapy
Ovarian Neoplasms pathology
Platinum pharmacology
Platinum therapeutic use
RNA Interference
Gene Expression Regulation, Neoplastic
MicroRNAs genetics
Ovarian Neoplasms genetics
Ovarian Neoplasms metabolism
Phosphatidylinositol 3-Kinases metabolism
Proto-Oncogene Proteins c-akt metabolism
Signal Transduction
TOR Serine-Threonine Kinases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1335
- Volume :
- 144
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of cancer research and clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 30109500
- Full Text :
- https://doi.org/10.1007/s00432-018-2737-y