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Potential of mesenchymal stromal cells for improving islet transplantation outcomes.
- Source :
-
Current opinion in pharmacology [Curr Opin Pharmacol] 2018 Dec; Vol. 43, pp. 34-39. Date of Electronic Publication: 2018 Aug 10. - Publication Year :
- 2018
-
Abstract
- Allogeneic islet transplantation as a therapy for Type 1 Diabetes (T1D) is restricted by the limited availability of donor islets, loss of functional islets during pre-transplantation culture in vitro and further extensive loss during the immediate post-transplantation period when islet function and survival is compromised by the hypoxic, inflammatory host environment. In the longer term pathogenic T cell responses drive autoimmunity and chronic allograft rejection. Experimental studies have demonstrated that mesenchymal stromal cells (MSCs) have significant potential to improve the outcomes of clinical islet transplantation. This review explores the potential for MSCs and their 'secretome' to influence donor islet cell function and survival, as well as the host niche. We discuss the possibility of harnessing the therapeutic benefits of MSCs in a cell-free strategy to offer a well-defined, cell-free approach to improve the outcomes of clinical islet transplantation.<br /> (Crown Copyright © 2018. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Biomarkers blood
Cell Differentiation
Cell Proliferation
Cell Survival
Diabetes Mellitus, Type 1 blood
Diabetes Mellitus, Type 1 immunology
Diabetes Mellitus, Type 1 pathology
Graft Rejection immunology
Graft Rejection prevention & control
Graft Survival
Humans
Islets of Langerhans immunology
Islets of Langerhans metabolism
Islets of Langerhans pathology
Islets of Langerhans Transplantation adverse effects
Mesenchymal Stem Cell Transplantation adverse effects
Phenotype
Recovery of Function
Regeneration
Risk Factors
Blood Glucose metabolism
Diabetes Mellitus, Type 1 surgery
Islets of Langerhans surgery
Islets of Langerhans Transplantation methods
Mesenchymal Stem Cell Transplantation methods
Mesenchymal Stem Cells immunology
Mesenchymal Stem Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1471-4973
- Volume :
- 43
- Database :
- MEDLINE
- Journal :
- Current opinion in pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 30103073
- Full Text :
- https://doi.org/10.1016/j.coph.2018.07.011