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Implication of gut microbiota metabolites in cardiovascular and metabolic diseases.
- Source :
-
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2018 Nov; Vol. 75 (21), pp. 3977-3990. Date of Electronic Publication: 2018 Aug 12. - Publication Year :
- 2018
-
Abstract
- Evidence from the literature keeps highlighting the impact of mutualistic bacterial communities of the gut microbiota on human health. The gut microbita is a complex ecosystem of symbiotic bacteria which contributes to mammalian host biology by processing, otherwise, indigestible nutrients, supplying essential metabolites, and contributing to modulate its immune system. Advances in sequencing technologies have enabled structural analysis of the human gut microbiota and allowed detection of changes in gut bacterial composition in several common diseases, including cardiometabolic disorders. Biological signals sent by the gut microbiota to the host, including microbial metabolites and pro-inflammatory molecules, mediate microbiome-host genome cross-talk. This rapidly expanding line of research can identify disease-causing and disease-predictive microbial metabolite biomarkers, which can be translated into novel biodiagnostic tests, dietary supplements, and nutritional interventions for personalized therapeutic developments in common diseases. Here, we review results from the most significant studies dealing with the association of products from the gut microbial metabolism with cardiometabolic disorders. We underline the importance of these postbiotic biomarkers in the diagnosis and treatment of human disorders.
- Subjects :
- Cardiovascular Diseases diagnosis
Cardiovascular Diseases microbiology
Cardiovascular Diseases pathology
Humans
Metabolic Diseases microbiology
Metabolic Diseases pathology
Biomarkers metabolism
Cardiovascular Diseases genetics
Gastrointestinal Microbiome genetics
Metabolic Diseases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1420-9071
- Volume :
- 75
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Cellular and molecular life sciences : CMLS
- Publication Type :
- Academic Journal
- Accession number :
- 30101405
- Full Text :
- https://doi.org/10.1007/s00018-018-2901-1