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Role of lipoprotein (a) and LPA KIV2 repeat polymorphism in bicuspid aortic valve stenosis and calcification: a proof of concept study.
- Source :
-
Internal and emergency medicine [Intern Emerg Med] 2019 Jan; Vol. 14 (1), pp. 45-50. Date of Electronic Publication: 2018 Aug 11. - Publication Year :
- 2019
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Abstract
- Hemodynamic valvular impairment is a frequent determinant of the natural history of bicuspid aortic valve (BAV). The role of elevated Lp(a) levels and LPA Kringle IV type 2 (KIV-2) size polymorphism in influencing aortic valve calcification and stenosis development in patients with tricuspid aortic valve was recognized. In this study, we investigate the association between Lp(a) and LPA KIV-2 repeat number, and the presence of calcification and stenosis in BAV patients. Sixty-nine patients [79.7% males; median age 45(30-53) yrs], consecutively referred to Center for Cardiovascular Diagnosis or Referral Center for Marfan syndrome or related disorders, AOU Careggi, from June to November 2014, were investigated. For each patient, clinical (ECG and echocardiography) and laboratory [Lp(a) (Immunoturbidimetric assay) and LPA KIV-2 repeat number (real-time PCR)] evaluation were performed. Patients were compared with 69 control subjects. No significant association between Lp(a) circulating levels and LPA KIV-2 repeat number and BAV was evidenced. Among BAV patients, significantly higher Lp(a) levels according to calcification degree were found [no calcifications:78(42-159) mg/L, mild/moderate: 134(69-189) mg/L; severe: 560(286-1511) mg/L, pā=ā0.008]. Conversely, lower LPA KIV-2 repeat numbers in subjects with more severe calcification degree were observed. Furthermore, higher Lp(a) levels in patients with aortic stenosis [214(67-501) mg/L vs 104(56-169) mg/L, pā=ā0.043] were also found. In conclusion, present data suggest the potential role for Lp(a) as a possible risk marker useful to stratify, among BAV patients, those with a higher chance to develop valvular calcifications and aortic stenosis.
- Subjects :
- Adult
Aortic Valve diagnostic imaging
Aortic Valve Stenosis blood
Aortic Valve Stenosis diagnostic imaging
Bicuspid Aortic Valve Disease
Biomarkers blood
Calcinosis blood
Calcinosis diagnostic imaging
Case-Control Studies
Echocardiography
Female
Genetic Predisposition to Disease
Genotype
Heart Valve Diseases blood
Heart Valve Diseases diagnostic imaging
Humans
Male
Middle Aged
Proof of Concept Study
Real-Time Polymerase Chain Reaction
Risk Factors
Aortic Valve abnormalities
Aortic Valve pathology
Aortic Valve Stenosis genetics
Calcinosis genetics
Heart Valve Diseases genetics
Kringles genetics
Lipoprotein(a) blood
Lipoprotein(a) genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1970-9366
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Internal and emergency medicine
- Publication Type :
- Academic Journal
- Accession number :
- 30099661
- Full Text :
- https://doi.org/10.1007/s11739-018-1925-8