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Exploring the Association of Asthma with Urinary Stone Disease: Results from the National Health and Nutrition Examination Survey 2007-2014.
- Source :
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European urology focus [Eur Urol Focus] 2020 Mar 15; Vol. 6 (2), pp. 354-360. Date of Electronic Publication: 2018 Aug 07. - Publication Year :
- 2020
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Abstract
- Background: The prevalence of urinary stone disease (USD) and asthma is rising and has recently been associated in a pediatric population.<br />Objective: To investigate the association between asthma and USD in a nationally representative adult population.<br />Design, Setting, and Participants: We analyzed the National Health and Nutrition Examination Survey 2007-2014, a US population-based cross-sectional study. A history of asthma and USD was obtained by self-report to questionnaires. USD severity was represented by graded stratification into non-stone formers, single stone formers, and recurrent stone formers (>2 stones).<br />Outcome Measurements and Statistical Analysis: Odds ratios (ORs) for asthma were calculated for respondents with USD and separately for the graded USD groups. Survey-weighted logistic regression models included adjustments for demographics (model A), medical information (model B), and for relevant medications (model C).<br />Results and Limitations: A total of 20 906 participants aged ≥20 yr were included in the analysis. Of these, 9.2% reported of having a history of kidney stones. Logistic regression analysis adjusted for demographics, medical conditions, and medications showed that stone formers had significantly increased odds of asthma (odds ratio=1.23; 95% confidence interval: 1.03-1.47; p=0.023). Separate logistic regression analysis demonstrated a graded association between single and recurrent stone formers and the odds of having asthma (p=0.01), which remained significant in the 20-50-yr-old population and the diabetic population, especially for recurrent stone formers. Causal relationships were limited by cross-sectional nature of the study.<br />Conclusions: Increasing severity of USD is associated with an increase in odds for asthma among American adults, providing impetus for future studies into the mechanisms explaining this phenomenon.<br />Patient Summary: In this report, we looked at self-reported histories of asthma and urinary stone disease (USD) using information from a large US population. We found that asthma was associated with USD; however, further studies are needed to elucidate this relationship.<br /> (Copyright © 2018 European Association of Urology. Published by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 2405-4569
- Volume :
- 6
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European urology focus
- Publication Type :
- Academic Journal
- Accession number :
- 30097392
- Full Text :
- https://doi.org/10.1016/j.euf.2018.07.035