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The association between oral disease and type of antiretroviral therapy among perinatally HIV-infected youth.
- Source :
-
AIDS (London, England) [AIDS] 2018 Nov 13; Vol. 32 (17), pp. 2497-2505. - Publication Year :
- 2018
-
Abstract
- Objectives: This study explores the association between combination antiretroviral therapy (cART) and oral health outcomes (dental and periodontal) among perinatally HIV-infected (PHIV) youth.<br />Methods: We conducted a cross-sectional study of oral health among PHIV youth participating in the Oral Health substudy of the Pediatric HIV/AIDS Cohort Study (PHACS). Dentists at research sites were trained/calibrated on how to perform a standardized oral mucosal, dental and periodontal examination. They assessed the decayed-missing-filled-surfaces and teeth index (DMFS/T). The number of decayed surfaces and teeth and the number of teeth with gingival bleeding on probing for each participant were derived from the examination. Data for analysis included lifetime measurements of CD4 cell count and viral load, sociodemographic information and current/past history of ART.<br />Results: Among 209 PHIV youth, 95% were on ART at the time of enrolment. Among 143 PHIV youth on the same cART for at least 1 year, we found that the mean decayed teeth score of those receiving cART containing an integrase inhibitor was 86% higher than that of those on cART without an integrase inhibitor after adjusting for age, lifetime proportion of unsuppressed viral load and CD4 cell count nadir. Initiating protease inhibitors before age 6 years was associated with a significantly lower DMFT score than participants who initiated at age 6 years and older.<br />Conclusion: Our study revealed that PHIV youth who received cART containing an integrase inhibitor had a significantly higher number of untreated active caries than those on cART without an integrase inhibitor. This may warrant closer dental surveillance of those receiving an integrase inhibitor.
- Subjects :
- Adolescent
CD4 Lymphocyte Count
Cross-Sectional Studies
Female
Humans
Male
Periodontal Diseases pathology
Stomatognathic Diseases pathology
Viral Load
Young Adult
Anti-Retroviral Agents administration & dosage
Antiretroviral Therapy, Highly Active methods
HIV Infections complications
HIV Infections drug therapy
Periodontal Diseases epidemiology
Stomatognathic Diseases epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5571
- Volume :
- 32
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 30096069
- Full Text :
- https://doi.org/10.1097/QAD.0000000000001965