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Protective immunity elicited by measles vaccine exerts anti-tumor effects on measles virus hemagglutinin gene-modified cancer cells in a mouse model.
- Source :
-
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2018 Oct; Vol. 144 (10), pp. 1945-1957. Date of Electronic Publication: 2018 Aug 06. - Publication Year :
- 2018
-
Abstract
- Purpose: Measles vaccine is widely used in China to prevent the measles virus (MV) infection. People immunized with measles vaccine can obtain long-term protective immunity. Measles virus surface glycoprotein hemagglutinin (H) can also induce MV-specific immune responses. However, little is known about whether the existence of the protective immune system against MV in the host can exert anti-tumor effects and whether the MV-H gene can serve as a therapeutic gene.<br />Methods: We first vaccinated mice with measles vaccine, then inoculated them with MV-H protein-expressing tumor cells and observed the rate of tumor formation. We also treated mice with H protein-expressing tumor cells with measles vaccine and assessed tumor size and overall survival.<br />Results: Active vaccination using measles vaccine not only protected mice from developing tumors, but also eradicated established tumors. Measles vaccine elicited H-specific IFN-γ, TNF-α and granzyme B-producing CD8+ T cells and increased cytotoxic T lymphocyte (CTL) activity specific for H antigen, which provided a strong therapeutic benefit against H protein-expressing tumors. In addition, measles vaccine decreased the population of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs).<br />Conclusions: Our study demonstrated that tumor cells expressing H protein could activate the immune memory response against MV, which exerted specific anti-tumor effects, and indicated that the MV-H gene can be used as a potential therapeutic gene for cancer gene therapy.
- Subjects :
- Animals
Hemagglutinins, Viral genetics
Humans
Interferon-gamma metabolism
Measles Vaccine immunology
Melanoma, Experimental genetics
Melanoma, Experimental immunology
Melanoma, Experimental pathology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Tumor Cells, Cultured
Vaccination
CD4-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes immunology
Disease Models, Animal
Hemagglutinins, Viral immunology
Measles Vaccine therapeutic use
Measles virus immunology
Melanoma, Experimental prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1335
- Volume :
- 144
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of cancer research and clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 30090962
- Full Text :
- https://doi.org/10.1007/s00432-018-2720-7