A Presynaptic Liquid Phase Unlocks the Vesicle Cluster.

Authors :: Wang SSH
Kaeser PS
Source :: Trends in neurosciences [Trends Neurosci] 2018 Nov; Vol. 41 (11), pp. 772-774. Date of Electronic Publication: 2018 Aug 04.
Publication Year :: 2018
Abstract: How are synaptic vesicles tied together in a nerve terminal? A recent study by Milovanovic and colleagues offers a new mechanism for this old and important problem: synapsin proteins establish a liquid phase that clusters vesicles. Liquid-liquid phase separation provides a fluid-like state that accommodates the dynamic demands of presynaptic vesicle traffic.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)