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Biology, role and therapeutic potential of circulating histones in acute inflammatory disorders.
- Source :
-
Journal of cellular and molecular medicine [J Cell Mol Med] 2018 Oct; Vol. 22 (10), pp. 4617-4629. Date of Electronic Publication: 2018 Aug 07. - Publication Year :
- 2018
-
Abstract
- Histones are positively charged nuclear proteins that facilitate packaging of DNA into nucleosomes common to all eukaryotic cells. Upon cell injury or cell signalling processes, histones are released passively through cell necrosis or actively from immune cells as part of extracellular traps. Extracellular histones function as microbicidal proteins and are pro-thrombotic, limiting spread of infection or isolating areas of injury to allow for immune cell infiltration, clearance of infection and initiation of tissue regeneration and repair. Histone toxicity, however, is not specific to microbes and contributes to tissue and end-organ injury, which in cases of systemic inflammation may lead to organ failure and death. This review details the processes of histones release in acute inflammation, the mechanisms of histone-related tissue toxicity and current and future strategies for therapy targeting histones in acute inflammatory diseases.<br /> (© 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.)
- Subjects :
- Alarmins blood
Alarmins genetics
Anti-Inflammatory Agents therapeutic use
Blood Coagulation Factors genetics
Blood Coagulation Factors immunology
Chemotactic Factors blood
Chemotactic Factors genetics
Chemotactic Factors immunology
Chemotaxis immunology
Communicable Diseases genetics
Communicable Diseases pathology
Communicable Diseases therapy
Extracellular Space chemistry
Extracellular Space immunology
Extracellular Traps chemistry
Extracellular Traps immunology
Gene Expression Regulation
Histones blood
Histones genetics
Humans
Immunity, Innate
Inflammation
Necrosis genetics
Necrosis pathology
Necrosis therapy
Neutrophils
Receptors, Pattern Recognition genetics
Signal Transduction
Thrombosis genetics
Thrombosis pathology
Thrombosis therapy
Alarmins immunology
Communicable Diseases immunology
Histones immunology
Necrosis immunology
Receptors, Pattern Recognition immunology
Thrombosis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1582-4934
- Volume :
- 22
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of cellular and molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 30085397
- Full Text :
- https://doi.org/10.1111/jcmm.13797