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Lack of Antidepressant Effects of Low-Voltage-Sensitive T-Type Calcium Channel Blocker Ethosuximide in a Chronic Social Defeat Stress Model: Comparison with (R)-Ketamine.
- Source :
-
The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2018 Nov 01; Vol. 21 (11), pp. 1031-1036. - Publication Year :
- 2018
-
Abstract
- Background: A recent study demonstrated that low-voltage-sensitive T-type calcium channel blocker ethosuximide shows rapid antidepressant actions. This study was conducted to compare the antidepressant actions of ethosuximide and (R)-ketamine in a chronic social defeat stress model.<br />Methods: Ethosuximide (100, 200, or 400 mg/kg), (R)-ketamine (10 mg/kg), or saline was administered i.p. to chronic social defeat stress-susceptible mice. Subsequently, locomotion test, tail suspension test, forced swimming test, and 1% sucrose preference test were performed.<br />Results: (R)-ketamine showed rapid and long-lasting antidepressant actions in chronic social defeat stress-susceptible mice. In contrast, ethosuximide did not attenuate the increased immobility time of tail suspension test and forced swimming test in chronic social defeat stress-susceptible mice. In the sucrose preference test, ethosuximide did not improve decreased sucrose preference in chronic social defeat stress-susceptible mice.<br />Conclusions: Unlike (R)-ketamine, ethosuximide did not show rapid and sustained antidepressant effects in a chronic social defeat stress model. Therefore, it is unlikely that low-voltage-sensitive T-type calcium channel inhibitors may have ketamine-like robust antidepressant actions.
- Subjects :
- Animals
Calcium Channels, T-Type metabolism
Disease Models, Animal
Dominance-Subordination
Dose-Response Relationship, Drug
Male
Mice, Inbred C57BL
Random Allocation
Stress, Psychological drug therapy
Treatment Failure
Antidepressive Agents pharmacology
Calcium Channel Blockers pharmacology
Depressive Disorder drug therapy
Ethosuximide pharmacology
Ketamine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1469-5111
- Volume :
- 21
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The international journal of neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 30085247
- Full Text :
- https://doi.org/10.1093/ijnp/pyy072