Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility.

Authors :: Healey KR
Kordalewska M
Jiménez Ortigosa C
Singh A
Berrío I
Chowdhary A
Perlin DS
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2018 Sep 24; Vol. 62 (10). Date of Electronic Publication: 2018 Sep 24 (Print Publication: 2018).
Publication Year :: 2018
Abstract: Multiple Erg11 amino acid substitutions were identified in clinical isolates of Candida auris originating from India and Colombia. Elevated azole MICs were detected in Saccharomyces cerevisiae upon heterologous expression of C. auris ERG11 alleles that encoded for Y132F or K143R substitutions; however, expression of alleles encoding I466M, Y501H, or other clade-defined amino acid differences yielded susceptible MICs. Similar to other Candida species, specific C. auris ERG11 mutations resulted directly in reduced azole susceptibility.<br /> (Copyright © 2018 Healey et al.)

Subjects :: Cytochrome P-450 Enzyme System genetics
Drug Resistance, Fungal genetics
Microbial Sensitivity Tests
Antifungal Agents pharmacology
Azoles pharmacology
Candida drug effects
Candida genetics
Mutation genetics

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