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Paclitaxel-Induced Ultrasmall Gallic Acid-Fe@BSA Self-Assembly with Enhanced MRI Performance and Tumor Accumulation for Cancer Theranostics.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2018 Aug 29; Vol. 10 (34), pp. 28483-28493. Date of Electronic Publication: 2018 Aug 20. - Publication Year :
- 2018
-
Abstract
- Ultrasmall nanoparticles have attracted great attention because of their efficient renal clearance. However, their bioapplication is still severely hampered by the poor performance derived from low tumor accumulation. Here, a large, self-assembled nanoparticle was designed for cancer theranostics and used with paclitaxel (PTX) to assemble bovine serum albumin-coated ultrasmall gallic acid-Fe(III) (GA-Fe@BSA-PTX) nanoparticles by the hydrophobic effect. The GA-Fe@BSA-PTX self-assembled nanoparticles featured appropriate size (∼115 nm), high water dispersity and stability, and low cell toxicity. Importantly, the magnetic resonance imaging performance and tumor accumulation of GA-Fe@BSA-PTX self-assembled nanoparticles were much better than those of the ultrasmall GA-Fe@BSA nanoparticles. Furthermore, the GA-Fe@BSA-PTX self-assembled nanoparticles exhibited an excellent therapeutic effect on tumors, owing to the combined chemo- and photothermal effects. This work highlights the great potential of the as-synthesized GA-Fe@BSA-PTX self-assembled nanoparticles as a multifunctional theranostic nanoplatform, offering compelling opportunities for theranostic applications in the clinic.
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 10
- Issue :
- 34
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 30080382
- Full Text :
- https://doi.org/10.1021/acsami.8b10625