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Improvement in treatment satisfaction after switching from liraglutide to dulaglutide in patients with type 2 diabetes: A randomized controlled trial.
- Source :
-
Journal of diabetes investigation [J Diabetes Investig] 2019 May; Vol. 10 (3), pp. 699-705. Date of Electronic Publication: 2018 Sep 19. - Publication Year :
- 2019
-
Abstract
- Aims/introduction: We compared treatment satisfaction in type 2 diabetes patients taking daily and weekly glucagon-like peptide-1 receptor agonists.<br />Materials and Methods: The study was a 12-week, multicenter, open-label, prospective, randomized, parallel-group comparison trial. The participants were Japanese patients with type 2 diabetes being administered with the glucagon-like peptide-1 receptor agonist, liraglutide, daily for >3 months. Patients were randomly assigned to either continue taking liraglutide once daily (Lira group) or switch to dulaglutide once weekly (Dula group). The primary outcome was the change in the Diabetes Treatment Satisfaction Questionnaire score from baseline to week 12 in the two groups. The secondary outcomes comprised changes in the Diabetes Therapy-Related Quality of Life score, body mass and glycemic control.<br />Results: A total of 33 participants were initially enrolled in the trial, and 31 participants completed the protocol. The change in the Diabetes Treatment Satisfaction Questionnaire score in the Dula group was significantly greater than that in the Lira group (+0.1 ± 4.7 in the Lira group vs +4.9 ± 5.2 in the Dula group; P = 0.013). The change in Diabetes Therapy-Related Quality of Life score in the Dula group was significantly greater than that in the Lira group (-3.7 ± 6.9 vs +8.9 ± 15.1; P = 0.007). There were no significant differences between groups in the changes in body mass, plasma glucose or glycated hemoglobin.<br />Conclusions: Weekly administration of dulaglutide was superior to liraglutide with regard to treatment satisfaction in patients with type 2 diabetes, in the absence of any negative effect on glycemic control.<br /> (© 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Blood Glucose analysis
Female
Follow-Up Studies
Glucagon-Like Peptides therapeutic use
Glycated Hemoglobin analysis
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Quality of Life
Biomarkers analysis
Diabetes Mellitus, Type 2 drug therapy
Glucagon-Like Peptides analogs & derivatives
Hypoglycemia prevention & control
Hypoglycemic Agents therapeutic use
Immunoglobulin Fc Fragments therapeutic use
Liraglutide therapeutic use
Personal Satisfaction
Recombinant Fusion Proteins therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 2040-1124
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of diabetes investigation
- Publication Type :
- Academic Journal
- Accession number :
- 30076787
- Full Text :
- https://doi.org/10.1111/jdi.12906