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Coccidioidomycosis in Nonhuman Primates: Pathologic and Clinical Findings.
- Source :
-
Veterinary pathology [Vet Pathol] 2018 Nov; Vol. 55 (6), pp. 905-915. Date of Electronic Publication: 2018 Aug 02. - Publication Year :
- 2018
-
Abstract
- Coccidioidomycosis in nonhuman primates has been sporadically reported in the literature. This study describes 22 cases of coccidioidomycosis in nonhuman primates within an endemic region, and 79 cases of coccidioidomycosis from the veterinary literature are also reviewed. The 22 cases included baboons ( n = 10), macaques ( n = 9), and chimpanzees ( n = 3). The majority died or were euthanized following episodes of dyspnea, lethargy, or neurologic and locomotion abnormalities. The lungs were most frequently involved followed by the vertebral column and abdominal organs. Microscopic examination revealed granulomatous inflammation accompanied by fungal spherules variably undergoing endosporulation. Baboons represented a large number of cases presented here and had a unique presentation with lesions in bone or thoracic organs, but none had both intrathoracic and extrathoracic lesions. Although noted in 3 cases in the literature, cutaneous infections were not observed among the 22 contemporaneous cases. Similarly, subclinical infections were only rarely observed (2 cases). This case series and review of the literature illustrates that coccidioidomycosis in nonhuman primates reflects human disease with a varied spectrum of presentations from localized lesions to disseminated disease.
- Subjects :
- Animals
Coccidioidomycosis microbiology
Coccidioidomycosis pathology
Female
Lung pathology
Macaca microbiology
Male
Microscopy, Electron veterinary
Pan troglodytes microbiology
Papio microbiology
Polymerase Chain Reaction veterinary
Primate Diseases microbiology
Coccidioidomycosis veterinary
Primate Diseases pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1544-2217
- Volume :
- 55
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Veterinary pathology
- Publication Type :
- Academic Journal
- Accession number :
- 30071801
- Full Text :
- https://doi.org/10.1177/0300985818787306