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Lesional and circulating levels of interleukin-17 and 25-hydroxycholecalciferol in active acne vulgaris: Correlation to disease severity.
- Source :
-
Journal of cosmetic dermatology [J Cosmet Dermatol] 2019 Apr; Vol. 18 (2), pp. 671-676. Date of Electronic Publication: 2018 Aug 02. - Publication Year :
- 2019
-
Abstract
- Objectives: The immunological aspects of inflammatory acne are still incompletely understood, so this study aimed to investigate the possible role of IL-17 and 25 hydroxycholecalciferol (25(OH)D3) in the disease pathogenesis and progression.<br />Materials and Methods: Across-sectional study has been conducted on 135 patients with active acne vulgaris of various severities and 150 matched controls. ELISA assays of serum and tissue levels of IL-17 and 25(OH)D3, also immunohistochemical and Western blotting demonstration of the expression patterns of lesional IL-17 in comparison with control group, were performed.<br />Results: The mean serum levels of IL-17 were 544.2 pg/mL ± 477.4 SD and 42.2 pg/mL ± 8.1 SD for acne patients and controls, respectively, with significantly higher levels among the patient group (P < 0.05). Higher IL-17 expression levels in active acne lesions when compared with its level in healthy skin of the controls. The mean serum levels of 25(OH)D3 among patients and controls were 33.3 ng/mL ± 9.7 SD and 51.7 ng/mL ± 2.7 SD, respectively, with significantly lower levels among the patient group (P < 0.05). There were significantly negative correlations between IL-17 and 25(OH)D3 levels (P < 0.001 for both).<br />Conclusions: Deficiency of vitamin D3 accompanied with higher IL-17 in an inverse pattern may have a possible role in active acne vulgaris.<br /> (© 2018 Wiley Periodicals, Inc.)
- Subjects :
- Acne Vulgaris blood
Acne Vulgaris diagnosis
Adult
Biomarkers blood
Biomarkers metabolism
Biopsy
Calcifediol metabolism
Case-Control Studies
Disease Progression
Female
Humans
Interleukin-17 immunology
Interleukin-17 metabolism
Male
Severity of Illness Index
Skin immunology
Vitamin D Deficiency blood
Young Adult
Acne Vulgaris immunology
Calcifediol blood
Interleukin-17 blood
Skin pathology
Vitamin D Deficiency immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1473-2165
- Volume :
- 18
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of cosmetic dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 30070012
- Full Text :
- https://doi.org/10.1111/jocd.12715