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Cognitive impairment in neuromuscular diseases: A systematic review.

Authors :: Orsini M
Carolina A
Ferreira AF
de Assis ACD
Magalhães T
Teixeira S
Bastos VH
Marinho V
Oliveira T
Fiorelli R
Oliveira AB
de Freitas MRG
Source :: Neurology international [Neurol Int] 2018 Jul 04; Vol. 10 (2), pp. 7473. Date of Electronic Publication: 2018 Jul 04 (Print Publication: 2018).
Publication Year :: 2018
Abstract: Neuromuscular diseases are multifactorial pathologies characterized by extensive muscle fiber damage that leads to the activation of satellite cells and to the exhaustion of their pool, with consequent impairment of neurobiological aspects, such as cognition and motor control. To review the knowledge and obtain a broad view of the cognitive impairment on Neuromuscular Diseases. Cognitive impairment in neuromuscular disease was explored; a literature search up to October 2017 was conducted, including experimental studies, case reports and reviews written in English. Keywords included Cognitive Impairment, Neuromuscular Diseases, Motor Neuron Diseases, Dystrophinopathies and Mitochondrial Disorders. Several cognitive evaluation scales, neuroimaging scans, genetic analysis and laboratory applications in neuromuscular diseases, especially when it comes to the Motor Neuron Diseases, Dystrophinopathies and Mitochondrial Disorders. In addition, organisms model using rats in the genetic analysis and laboratory applications to verify the cognitive and neuromuscular impacts. Several studies indicate that congenital molecular alterations in neuromuscular diseases promote cognitive dysfunctions. Understanding these mechanisms may in the future guide the proper management of the patient, evaluation, establishment of prognosis, choice of treatment and development of innovative interventions such as gene therapy.<br />Competing Interests: Conflict of interest: the authors declare no potential conflict of interest.